A possible susceptibility locus for bipolar affective disorder in chromosomal region 10q25–q26
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چکیده
منابع مشابه
A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22.
Bipolar disorder or manic depressive illness is a major psychiatric disorder that is characterized by fluctuation between two abnormal mood states. Mania is accompanied by symptoms of euphoria, irritability, or excitation, whereas depression is associated with low mood and decreased motivation and energy. The etiology is currently unknown; however, numerous family, twin, and adoption studies ha...
متن کاملA genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q.
Bipolar affective disorder (BPAD), also known as manic depressive illness, is a severe psychiatric disorder characterized by episodes of mania and depression. It has a lifetime prevalence of approximately 1% in all human populations. In order to identify chromosomal regions containing genes that play a role in determining susceptibility to this psychiatric condition, we have conducted a complet...
متن کاملScreening of chromosomal region 21q22.3 for mutations in genes associated with neuronal Ca2+ signalling in bipolar affective disorder.
The therapeutic effect of lithium in bipolar affective disorder may be connected with decreasing intracellular Ca(2+) concentrations. Several linkage studies have identified a potential bipolar affective disorder susceptibility locus within chromosomal region 21q22.3. This locus contains two genes expressed in the brain - ADARB1 and TRPM2 - involved in regulating intracellular Ca(2+) concentrat...
متن کاملLinkage studies suggest a possible locus for bipolar disorder near the velo-cardio-facial syndrome region on chromosome 22.
Velo-cardio-facial syndrome (VCFS) is a congenital anomaly characterized by multiple dysmorphisms, cleft palate, cardiac anomalies, and learning disabilities, that results from a microdeletion of chromosome 22q11. An increased prevalence of psychiatric illness has been observed, with both schizophrenia and bipolar disorder commonly being diagnosed. For these reasons, the VCFS region is an inter...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2001
ISSN: 1359-4184,1476-5578
DOI: 10.1038/sj.mp.4000864